Tendon 2 Ligament Mechanobiology by Jasper Foolen de la Eindhoven University of Technology

14 octubre, 2021

Organizado por

BCMaterials

14/10/2021. 10:00 Horas

Online mediante plataforma Teams. https://teams.microsoft.com/l/meetup-join/19%3ameeting_ZTFmMjY0MzctOTNiMC00ZjczLTkzN2EtN2JkYmE4Mzc2NTFm%40thread.v2/0?context=%7b%22Tid%22%3a%222f54ab68-83af-4d70-8895-a0d1e95ec899%22%2c%22Oid%22%3a%227778b4e1-e06d-485b-b530-cf013d4e9498%22%2c%22IsBroadcastMeeting%22%3atrue%7d&btype=a&role=a

Dr. Jasper Foolen:

Tendon 2 Ligament Mechanobiology

Assistant Professor at the Orthopaedic Biomechanics group of the department of Biomedical Engineering

Eindhoven University of Technology, Netherlands

 

ABSTRACT

In my talk I will explain how I attempt to pursue my ultimate goal, which is to develop materials, tools and strategies that can assist in optimizing the quality of life of patients that suffer from tendon and ligament issues. Tendon and ligament injuries are involved in over 30% of all musculoskeletal consultations. Over the past decades there has been limited progress in the treatment of tendinopathy and connective tissue fibrosis (scarring). It suffers from poor innate regenerative capacity, the clinical outcome of surgical interventions has remained rather poor and there is controversy concerning adequate treatment. I thus explore the mechanobiological processes that initiate degeneration and promote healing of tendons and ligaments. Experimental platforms that we developed were exploited, in combination with numerical models, to develop strategies to improve the structure and functionality of affected tendons and ligaments. In my talk I will address these model systems, which mimic specific material properties of in vivo tissue, and elaborate on the science that we derived from them.

Title: Tendon 2 Ligament Mechanobiology.

Research profile/interests: Jasper Foolen is Assistant Professor at the Orthopaedic Biomechanics group of the department of Biomedical Engineering. His main research interest is mechanobiology and regenerative strategies of tendons and ligaments. Tendon and ligament injuries are involved in over 30% of all musculoskeletal consultations. Over the past decades there has been limited progress in the treatment of tendinopathy and connective tissue fibrosis (scarring). It suffers from poor innate regenerative capacity, the clinical outcome of surgical interventions has remained rather poor and there is controversy concerning adequate treatment. In his research, Jasper Foolen explores the mechanobiological processes that initiate degeneration and promote healing of tendons and ligaments. Experimental platforms (e.g. biomimetic tendons and ligaments) are exploited in combination with numerical models, to develop strategies to improve the structure and functionality of affected tendons and ligaments. Ultimately, his goal is to develop materials, tools and screening methods that improve the quality of life of patients that suffer from tendon and ligament issues.

Biography: Jasper Foolen studied Mechanical Engineering at Fontys University for Higher Education (Eindhoven, The Netherlands) and obtained his BSc in 2000. He then started his study in Biomedical Engineering at Eindhoven University of Technology (TU/e) where he obtained his BSc in 2003 and his MSc in 2005. From 2005 – 2009, he was a PhD student at the TU/e research group Orthopedic Biomechanics. In 2009 Foolen obtained his PhD with his thesis ‘How periosteum is involved in long bone growth’ under supervision of professors Keita Ito, Rik Huiskes and René van Donkelaar. From 2009 – 2013, he was a Postdoctoral Fellow at the TU/e research group for Soft Tissue Biomechanics and Engineering. In 2013 Foolen moved to Switzerland to become a Marie Curie Fellow at the Lab of Applied Mechanobiology at ETH Zurich. From 2015 – 2016, he was Group Leader at the Lab for Orthopaedic Biomechanics of University Hospital Balgrist / ETH Zurich. In 2016 Jasper Foolen was appointed Assistant Professor in Tendon and Ligament Mechanobiology at the TU/e research group Orthopedic Biomechanics.